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2’3’-c-di-AM(PS)2 (Rp,Rp) is the Rp,Rp-isomer of the 2’3’ bisphosphorothioate analog of 3’3’-cyclic adenosine monophosphate (c-di-AMP). c-di-AMP is second messenger molecule produced by bacteria wi…

2’3’-cGAMP (cyclic [G(2’,5’)pA(3’,5’)p]) is produced in mammalian cells by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm.2’3’-cGAMP is also referred to as “noncanonical“……

5’ triphosphate double-stranded RNA (5’ppp-dsRNA) is a synthetic ligand for the retinoic acid-inducible protein I (RIG-I, also known as Ddx58). RIG-I is a cytoplasmic RNA helicase that belongs to the…

Anti-mPD-1-mIgG1e3 InvivoFit™ is a recombinant monoclonal antibody (mAb) featuring the variable region of the previously described anti-mPD-1 RMP1-14 mAb [1, 2]. The original RMP1-14 hybridoma was ob…

Adenosine triphosphate (ATP), a potassium efflux agent, can trigger the activation of NLRP3 inflammasome in response to PAMPs, such as LPS and peptidoglycan.It stimulates the caspase-1-dependent cle……

Beta-glucan peptide (BGP) is a high molecular weight (~100 kDa) polysaccharide extracted from the fungus Trametes versicolor. BGP consists of a highly ramified glucan portion, comprising a beta 1-4…

Bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) is a second messenger produced in bacteria but not in mammals. This cyclic dinucleotide is involved in complex biological processes, such…

E. coli outer membrane vesicles (OMVs) - Caspase 11-4/5 inducers Outer membrane vesicles (OMVs) are small, spherical bodies secreted by Gram-negative bacteria, recently described as potent caspase ……

FLA-ST is flagellin isolated from the Gram-negative bacteria Salmonella typhimurium. InvivoGen provides FLA-ST with two grades of purity: FLA-ST was purified by acid hydrolysis, heating and ultrafi…

Fungin™ is used as a “routine addition“ to eukaryotic cell culture media to prevent fungal contaminations. It can also be used to eliminate fungal contaminations. This antimycotic compound kills ye…