The 116-13.1 monoclonal antibody reacts with the Lyt 2.1 allele of mouse CD8. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily expressed on the surface of cytotoxic T cells but can also be found on thymocytes natural killer cells and some dendritic cell subsets. CD8 most commonly exists as a heterodimer composed of one CD8α and one CD8β chain however it can also exist as a homodimer composed of two CD8α chains. Both the CD8α and CD8β chains share significant homology to immunoglobulin variable light chains. The molecular weight of each CD8 chain is approximately 34 kDa. The 116-13.1 antibody exhibits depleting activity in NOD mice when used in vivo. This antibody does not function in C57BL/6 or BALB/c strains since these strains only express the Lyt 2.2 allele of CD8.

產(chǎn)品名稱(chēng):InVivoMab anti-mouse CD8 (Lyt 2.1)

反應(yīng)種屬:mouse

宿主來(lái)源:mouse

實(shí)驗(yàn)應(yīng)用:in vivo CD8+ T cell depletion, Flow cytometry

同種型:IgG2a

免疫原:CE mouse spleen cells and thymocytes

克隆性:Monoclonal

克隆號(hào):116-13.1 (HB-129)

產(chǎn)品濃度:Lot specific,typically between 4-11 mg/ml

保存溫度:Undiluted at 4°C in the dark

運(yùn)輸溫度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

預(yù)期分子量:150 kDa

產(chǎn)品形式:液體

有效期:One year from the date of receipt if stored as recommended

產(chǎn)地:美國(guó)

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